王焱

教授/主任医师/博导

医生简介

学科（专业）:内科学（心血管）

研究方向：心血管疾病的临床与基础研究

邮箱：wy@medmail.com.cn

电话：0592-2292320

教育背景：

1985-1990 西安医科大学临床医学本科

1993-1996 新疆医科大学心血管内科硕士

1999-2004 香港大学医学院心血管内科博士

工作经历：

1990.07-1996.09 新疆医科大学附属第一医院心内科主治医师

1996.07-2001.07 香港玛丽医院心内科注册医师

2002.07-2003.07 香港圣保禄医院心内科注册医师

2001.03-2014.12 厦门大学附属中山医院心内科主任医师

2015.01-2016.08 厦门市心血管病医院（厦门市心脏中心）院长

2016.09- 至今厦门大学附属心血管病医院（厦门市心脏中心）院长

主要研究领域：

王焱教授长期从事心血管转化医学研究，主要兴趣在心脏介入临床研究、动脉粥样硬化机制与临床研究、缺血再灌注损伤与心肌保护研究、心脏干细胞移植治疗、离子通道与心律失常发病机制研究，中药对心血管疾病治疗作用研究等；近年来以第一/通讯作者在国际知名杂志发表论著20余篇；承担国家自然科学基金重点项目、国家科技部重点研发项目等国家、省、市级科研项目10余项，科研经费超过2000万元。

主要学术成果：

论文（*为通讯作者）：

1. . Xiang D, Xiang X, Zhang W, Yi S, Zhang J, Gu X, Xu Y, Huang K, Su X, Yu B, Wang Y, Fang W, Huo Y, Ge J. Management and Outcomes of Patients With STEMI During the COVID-19 Pandemic in China. J Am Coll Cardiol. 2020; 76: 1318-24.

2. Song F, Zhou XX, Hu Y, Li G*, Wang Y*. The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases. Adv Ther. 2020.

2. Wu Y, Song F, Li Y, Li J, Cui Y, Hong Y, Han W, Wu W, Lakhani I, Li G*, Wang Y*. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-/-) Mice. J Cell Mol Med. 2020.

3. Fu R, Song C, Yang J, Gao C, Wang Y, Xu H, Gao X, Fan X, Xu H, Wang H, Dou K, Yang Y, Study CR. A Practical Risk Score to Predict 24-Month Post-Discharge Mortality Risk in Patients With Non-ST-Segment Elevation Myocardial Infarction. Circ J. 2020; 84: 1974-80.

4. Ni E, Fang Y, Ma F, Ge G, Wu J, Wang Y, Lin Y, Xie H. A one-step potentiometric immunoassay for plasma cardiac troponin I using an antibody-functionalized bis-MPA-COOH dendrimer as a competitor with improved sensitivity. Anal Methods. 2020; 12: 2914-21.

5. Wu WY, Cui YK, Hong YX, Li YD, Wu Y, Li G, Li GR, Wang Y*. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules. J Cell Mol Med. 2020; 24: 12141-53.

6. Guo J, Li L, Xiao G, Huang X, Li Q, Wang Y, Cai B. Feasibility and stability of left bundle branch pacing in patients after prosthetic valve implantation. Clin Cardiol. 2020; 43: 1110-8.

7. Wang Y*, Xiao G, Zhang G, Wang B, Lin Z, Saiwha HD, You H, Lai K, Su M, Wen H, Wang J, Annest L, Tse G. Early Results of the Revivent TC Procedure for Treatment of Left Ventricular Aneurysm and Heart Failure due to Ischemic Cardiomyopathy. EuroIntervention. 2020.

8. Zhang K, Wu WY, Li G, Zhang YH, Sun Y, Qiu F, Yang Q, Xiao GS, Li GR, Wang Y*. Regulation of the TRPC1 channel by endothelin-1 in human atrial myocytes. Heart Rhythm. 2019; 16: 1575-83.

9. Zhang R, Jie LJ, Wu WY, Wang ZQ, Sun HY, Xiao GS, Wang Y, Li YG, Li GR. Comparative study of carvedilol and quinidine for inhibiting hKv4.3 channel stably expressed in HEK 293 cells. Eur J Pharmacol. 2019; 853: 74-83.

10. Chang H, Zhao F, Xie X, Liao Y, Song Y, Liu C, Wu Y, Wang Y, Liu D, Wang Y, Zou J, Qi Z. PPARalpha suppresses Th17 cell differentiation through IL-6/STAT3/RORgammat pathway in experimental autoimmune myocarditis. Exp Cell Res. 2019; 375: 22-30.

11. Li G, Che H, Wu WY, Jie LJ, Xiao GS, Wang Y*, Li GR*. Bradykinin-mediated Ca(2+) signalling regulates cell growth and mobility in human cardiac c-Kit(+) progenitor cells. J Cell Mol Med. 2018; 22: 4688-99.

12. Guo JC, Huang WB, Zhou FG, Hong J, Wang Y*. Sustained localized reentry within the left atrial appendage as a mechanism of recurrent arrhythmia following atrial fibrillation ablation. Exp Ther Med. 2018; 16: 772-8.

13. Li G, Song Y, Li YD, Jie LJ, Wu WY, Li JZ, Zhang Q, Wang Y*. Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure. Biomark Med. 2018; 12: 871-80.

14. Xiao GS, Zhang YH, Wang Y, Sun HY, Baumgarten CM, Li GR. Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes. Br J Pharmacol. 2018; 175: 3422-32.

15. Wu WY, Li YD, Cui YK, Wu C, Hong YX, Li G, Wu Y, Jie LJ, Wang Y*, Li GR*. The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2018; 9: 497.

16. Chen KH, Liu H, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR*. The Natural Flavone Acacetin Blocks Small Conductance Ca(2+)-Activated K(+) Channels Stably Expressed in HEK 293 Cells. Front Pharmacol. 2017; 8: 716.

17. Deng XL, Wang Y, Xiao GS. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells. PLoS One. 2017; 12: e0183708.

18. Wang Y, Sun HY, Liu YG, Song Z, She G, Xiao GS, Wang Y, Li GR, Deng XL. Tyrphostin AG556 increases the activity of large conductance Ca(2+) -activated K(+) channels by inhibiting epidermal growth factor receptor tyrosine kinase. J Cell Mol Med. 2017; 21: 1826-34.

19. Li G, Wang Y*, Li GR*. Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells. Oncotarget. 2017; 8: 10822-35.

20. Xiao GS, Zhang YH, Wu W, Sun HY, Wang Y, Li GR*. Genistein and tyrphostin AG556 decrease ultra-rapidly activating delayed rectifier K(+) current of human atria by inhibiting EGF receptor tyrosine kinase. Br J Pharmacol. 2017; 174: 454-67.

21. Jie LJ, Wu WY, Li G, Xiao GS, Zhang S, Li GR*, Wang Y*. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. Br J Pharmacol. 2017; 174: 254-66.

22. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR*. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016; 6: 36435.

23. Wang Y, Wang Y*, Li GR*. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 2016; 7: 50937-51.

24. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR*. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016; 6: 25743.

25. Che H, Xiao GS, Sun HY, Wang Y*, Li GR*. Functional TRPV2 and TRPV4 channels in human cardiac c-kit(+) progenitor cells. J Cell Mol Med. 2016; 20: 1118-27.

26. Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2016; 104: 61-9.

27. Chen KH, Xu XH, Sun HY, Du XL, Liu H, Yang L, Xiao GS, Wang Y, Jin MW, Li GR. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes. Heart Rhythm. 2016; 13: 762-70.

28. Che H, Li G, Sun HY, Xiao GS, Wang Y, Li GR*. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015; 309: H1772-81.

29. Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y*, Li GR*. Effects of BKCa and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit+ Progenitor Cells. PLoS One. 2015; 10: e0138581.

30. Wang B, Wang Y*. Acute coronary syndrome caused by left main coronary artery compression between the aortic root and massive dilation of the left atrium. Can J Cardiol. 2015; 31: 227 e3-5.

31. Wang B, Wang Y, Ye T, Xiao G, Chang H, Wen H, Chen Y, Lin J, Yang L, Ye J, Huang L, Chen L, Cui Y, Fan C, Wu Y, Zheng Q. [Integrated regional network construction for ST-segment elevation myocardial infarction care]. Zhonghua Xin Xue Guan Bing Za Zhi. 2014; 42: 650-4.

32. Chang H, Wang Y, Wu W, Li G, Hanawa H, Zou J. Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization. Int J Mol Med. 2013; 31: 833-40.

33. Wang Y, Li G, Tang JX, Chang H. [Time course of interleukin-21 and related cytokines expression in rats with experimental autoimmune myocarditis]. Zhonghua Xin Xue Guan Bing Za Zhi. 2012; 40: 43-9.

34. Wang Y, Chang H, Zou J, Jin X, Qi Z. The effect of atorvastatin on mRNA levels of inflammatory genes expression in human peripheral blood lymphocytes by DNA microarray. Biomed Pharmacother. 2011; 65: 118-22.

科研项目（部分）：

1.国家自然科学基金海峡联合基金项目，心脏祖细胞在心肌梗死修复中的机制研究，2017.01-2020.01，主持

2.科技部重点研发项目，急性心肌梗死全程心肌保护体系研究，2016.09-2020.12

3.厦门市科技局重大科技平台项目，冠心病急症的远程诊断和区域协同救治平台二期，2015.10-2018.09，主持

4.厦门市重大疾病联合公关项目，经导管主动脉瓣植入在高危重度主动脉瓣狭窄合并左室功能不全患者中的临床应用研究，2015.01-2017.12，主持

5.福建省科技厅重点项目，经皮导管肾脏去神经法治疗顽固性高血压的临床技术研究2014.01-2017.01，主持

6.国家自然基金面上项目，Kv1.3 通道在动脉粥样硬化中的作用研究，2009.01-2011.12，主持

获奖：

1.2016年福建省科学技术奖一等奖，急性冠脉综合征区域协同救治体系的创新及应用示范

2.2015年厦门市重大贡献奖，全市覆盖区域协同胸痛急救网络

3.2014年厦门市科学技术奖三等奖，CD4+T淋巴细胞Kv1.3通道在大鼠动脉粥样硬化中的作用研究

4.2014年中国医师奖（第九届）

5.2016年厦门市医学创新奖，经导管主动脉瓣植入术的临床应用及推广

6.2015年厦门市医学创新奖，区域协同ST段抬高型心肌梗死救治网络建设及临床应用

7.2014年厦门市医学创新奖，冠脉内压力导丝技术在冠脉造影临界病变中的应用