李刚

助理研究员

医生简介

研究方向：心血管疾病的转化医学研究

邮箱： ligang@xmu.edu.cn；gangli1982@outlook.com。

电话：0592-2292705

教育背景：

2001.09-2005.06 西北大学生物科学本科

2007.09-2010.06 厦门大学心血管药理学硕士

2013.09-2017.06 厦门大学心血管生理学博士

工作经历：

2010.07-至今厦门大学附属心血管病医院（厦门市心脏中心）助理研究员

2013.09-2015.03．香港大学李嘉诚医学院访问学者

主要研究领域：

长期从事心血管疾病的转化医学研究，主要关注非编码RNA和外泌体对动脉粥样硬化机制研究、缺血再灌注损伤与心肌保护的研究；近年来以第一/通讯作者在国际知名杂志发表论著7篇；参与国家自然科学基金海峡联合基金项目等国家、省、市级科研项目10余项。

研究成果：

论文（*为通讯作者）

1. Wu Y, Song F, Li Y, Li J, Cui Y, Hong Y, Han W, Wu W, Lakhani I, Li G*, Wang Y*. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-/-) Mice. J Cell Mol Med. 2020.

2. Yan P, Wu X, Cai F, Chen Y, Huang Y, Li G*, Lai K*. Efficacy and safety of sugammadex in anesthesia of cardiac surgery: A retrospective study. J Clin Anesth. 2020; 65: 109845.

2. Wu WY, Cui YK, Hong YX, Li YD, Wu Y, Li G, Li GR*, Wang Y*. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK/Nrf2 signal molecules. J Cell Mol Med. 2020; 24: 12141-53.

3. Song Y, Song F, Wu C, Hong YX, Li G*. The roles of epicardial adipose tissue in heart failure. Heart Fail Rev. 2020.

4. Song F, Zhou XX, Hu Y, Li G*, Wang Y*. The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases. Adv Ther. 2020.

6. Zhang K, Wu WY, Li G, Zhang YH, Sun Y, Qiu F, Yang Q, Xiao GS, Li GR*, Wang Y*. Regulation of the TRPC1 channel by endothelin-1 in human atrial myocytes. Heart Rhythm. 2019; 16: 1575-83.

7. Wu WY, Li YD, Cui YK, Wu C, Hong YX, Li G, Wu Y, Jie LJ, Wang Y*, Li GR*. The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2018; 9: 497.

8. Li G*, Song Y, Li YD, Jie LJ, Wu WY, Li JZ, Zhang Q, Wang Y*. Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure. Biomark Med. 2018; 12: 871-80.

9. Li G, Che H, Wu WY, Jie LJ, Xiao GS, Wang Y*, Li GR*. Bradykinin-mediated Ca(2+) signalling regulates cell growth and mobility in human cardiac c-Kit(+) progenitor cells. J Cell Mol Med. 2018; 22: 4688-99.

10. Li G, Wang Y, Li GR. Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells. Oncotarget. 2017; 8: 10822-35.

11. Jie LJ, Wu WY, Li G, Xiao GS, Zhang S, Li GR, Wang Y. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. Br J Pharmacol. 2017; 174: 254-66.

12. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR*. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016; 6: 36435.

13. Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y*, Li GR*. Effects of BKCa and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit+ Progenitor Cells. PLoS One. 2015; 10: e0138581.

14. Che H, Li G, Sun HY, Xiao GS, Wang Y*, Li GR*. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015; 309: H1772-81.

课题：

1.国家自然科学基金海峡联合基金项目，心脏祖细胞在心肌梗死修复中的机制研究，2017.01-2020.01，参与

获奖：

1.2014年厦门市科学技术奖三等奖 CD4+T淋巴细胞Kv1.3通道在大鼠动脉粥样硬化中的作用研究。

2. 2014年厦门市科学技术奖三等奖体外重组裸质粒构建及对免疫性心肌炎的基因治疗研究及应用推广。