郑锦荣
学科（专业）：生物医学工程
研究方向：分子影像与功能性分子识别
邮箱：zhengjinrong1989@163.com
电话：18851100236
教育背景：
1. 2009.9-2013.6 天津中医药大学, 中药学, 理学学士
2. 2014.9-2017.6 中国药科大学, 中西医结合基础（药学）, 理学硕士
3. 2017.9-2020.6 中国药科大学, 药学（制药工程学）, 理学博士
工作经历：
2020.10-至今 厦门大学附属心血管病医院（厦大医学院心血管病研究所）任职副研究员
主要研究领域：
（1）设计并合成刺激响应型诊疗一体小分子药物用于动脉粥样硬化、深静脉血栓等心血管疾病的多模态成像与特异性治疗；
（2）以活细胞作为改造平台，通过对活细胞进行特异性表面修饰与内部标记获得以细胞为识别单元的诊断介质，用于心血管疾病的多模态成像与实时诊断；
（3）基于光学检测技术发展心血管疾病特异性治疗药物、高效递药系统的高通量筛选方法。
主要学术成果：
1. Jinrong Zheng, Yue Xu, Lixue Fan, et al. A Bioresponsive Near infrared Fluorescent Probe for Facile and Persistent Live cell Tracking[J]. Small, 2020, 16(33). (IF=11.459)
2. Jinrong Zheng, Yuanzhi Shen, Zhiqiang Xu, et al. Near-infrared off-on fluorescence probe activated by NTR for in vivo hypoxia imaging[J]. Biosens. Bioelectron. 2018, 119, 141-148. (IF=10.257)
3. Jinrong Zheng, Shuheng Qin, Hua Li, et al. Light-up lipid droplets for the visualization of lipophagy and atherosclerosis by coumarin-derived bioprobe[J]. Chinese Chemical Letters, 2020, Revised. (IF=4.632)
4. Jinrong Zheng, Jianlong Li, Hongli Luo, et al. Controlled “off-on” Fluorescent Probe for the Specific Detection of Hyperhomocysteinemia[J]. RSC Advances, 2020, Revised. (IF=3.119)
5. Kefeng Zhai, Jinrong Zheng, Youmei Tang, et al. The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis[J]. British journal of pharmacology, 2017. 174(17):2818-2831. (IF=7.73)
6. FeiWang, Zhenwei Yuan,Patrick McMullen, Ruixi Li, Jinrong Zheng, Yue Xu, Mingjun Xu, QingHe, Bowen Li and Haiyan Chen. Near-Infrared-Light Responsive Lipid Nanoparticles as An Intelligent Drug Release System for Cancer Therapy[J]. Chem. Mater.2019, 31(11): 3948-3956. (IF=9.567)
7. Zhenwei Yuan, Lijuan Gui, Jinrong Zheng, Yisha Chen, Sisi Qu, Yuanzhi Shen, Fei Wang, Murat Er,Yueqing Gu, and Haiyan Chen. GSH-Activated Light-Up Near-Infrared Fluorescent Probe with High Affinity to αvβ3 Integrin for Precise Early Tumor Identification[J]. ACS Appl. Mater. Interfaces, 2018, 10, 30994-31007. (IF=8.758)
8. Li Liang, Weiqing Li, Jinrong Zheng, Ruixi Li, Haiyan Chen, Zhenwei Yuan. A new lysosome-targetable fluorescent probe for detection of endogenous hydrogen polysulfides in living cells and inflamed mouse model. Biomaterials Science,2020, 8(1):224-231. (IF=6.183)
9. Lijuan Gui, Zhenwei Yuan, Habtamu Kassaye, Jinrong Zheng, Yuxin Yao, Fei Wang, Qing He, Yuanzhi Shen, Li Liang, and Haiyan Chen. A tumor-targeting probe based on a mitophagy process for live imaging. Chem. Commun., 2018,54, 9675-9678. (IF=5.996)
10. Li Li, Yue Xu, Yisha Chen, Jinrong Zheng, Juanjuan Zhang, Ruixi Li, Hao Wan, Jun Yin, Zhenwei Yuan, Haiyan Chen. A family of push-pull bio-probes for tracking lipid droplets in living cells with the detection of heterogeneity and polarity. Analytica Chimica Acta, 2020, 1096:166-173. (IF=5.977)
11. Chen Wei, Zhenwei Yuan, Jinrong Zheng, Habtamu Kassaye, Lijuan Gui, Fei Wang, Hao Wan, Yue Xu, Qing He, Murat Er, Yi Ma, and Haiyan Chen. Methionine-Decorated Near Infrared Fluorescent Probe for Prolonged Tumor Imaging. Mol. Pharm.2018, 15, 3167-3176. (IF=4.321)
12. Ruixi Li, Juanjuan Zhang, Jingxuan Guo, Yue Xu, Kunyuan Duan, Jinrong Zheng, Hao Wan, Zhenwei Yuan, Haiyan Chen. Application of nitroimidazole-carbobane-modified phenylalanine derivatives as dual-target boron carriers in boron neutron capture therapy. Molecular Pharmaceuticals, 2020, 17(1): 202-211. (IF=4.321)
13. Qing He, Ruixi Li, Zhenwei Yuan, Habtamu Kassaye, Jinrong Zheng, Chen Wei,Fei Wang, Yuxin Yao, Lijuan Gui and Haiyan Chen. A turn-on near-infrared fluorescent probe for detection of cysteine over glutathione and homocysteine in vivo. Anal. Methods, 2019,11, 1857-1867.(IF=2.073)
14. Li Liang, Shuwen Peng, Zhenwei Yuan, Chen Wei, Yuanyuan He, Jinrong Zheng, Yueqing Gu, Haiyan Chen. Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy. RSC Advance., 2018, 8, 6013. (IF=2.936)
获奖情况：
1. 2019年获得“国家奖学金”
2. 2020年获得“威尔曼优秀博士学位论文”
