吴俊

副研究员

医生简介

学科（专业）：生命科学

研究方向：心血管疾病的发病机制及药物研究

邮箱：wujun229@126.com

电话：0592-2292705

教育背景：

2005-2009，南阳师范学院，生物工程，本科

2009-2012，厦门大学，生物化学与分子生物学，硕士

2014-2019，厦门大学，化学生物学，博士

2016-2018，美国加州大学伯克利分校，联合培养博士

工作经历：

2012.06-2014.05 厦门大学药学院实验员

2019.09-2020.06 厦门大学药学院科研助理

2020.08-2022.07 厦门大学生物学流动站博士后

2022.08-2023.02 厦门飞朔生物技术有限公司项目经理

2023.03-至今厦门大学附属心血管病医院副研究员

主要研究领域：

吴俊博士长期从事重大疾病相关的发病机制及其药物研发工作，目前主要聚焦于转录因子在心血管疾病的发生发展过程中的调控机制及靶向相关通路的药物开发。近年来在国际知名杂志发表论著10余篇；承担中国博士后科学基金一项（已结题）。

研究成果：

论文（# 为共一作者）

1. Jun Wu; Yuhua Xue; Xiang Gao; Qiang Zhou*. Host cell factors stimulate HIV-1 transcription by antagonizing Substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2, Nucleic Acids Research, 2020, 48 (13): 7321-7332. (IF=19.16)

2. Mingtao Ao#; Jun Wu#; Yin Cao; Yaohui He; Yuxiang Zhang; Xiang Gao; Yuhua Xue*; Meijuan Fang*; Zhen Wu*.The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9. Chinese Chemical letters, 2023, 34(4) . (IF=9.1)

3. Jun Wu#; Hongyu Hu#; Mingtao Ao#; Zhenzhen Cui; Xiaoping Zhou; Jingbo Qin; Yafei Guo; Jingwei Chen; Yuhua Xue*; Meijuan Fang*. Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent, Journal of Enzyme Inhibition and Medicinal Chemistry, 2021,36 (1) :1436-1453. (IF=5.75 )

4. Jun Wu#; Mingtao Ao#; Rui Shao; Huiru Wang; Diao Yu; Meijuan Fang; Xiang Gao; Zhen Wu*; Qiang Zhou*; Yuhua Xue*. A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter, Scientific Reports, 2017, 7 (1): 10657. (IF = 4.99)

5. Hongyu Hu#; Jun Wu#; Mingtao Ao#; Xiaoping Zhou; Boqun Li; Zhenzhen Cui; Tong Wu; Lijuan Wang; Yuhua Xue*;Zhen Wu*; Meijuan Fang*. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(Py-ridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold:Novel potential CDK9 inhibitors. Bioorganic Chemistry, 2020,102,104064. (IF=5.3)

6. Jun Wu#; Yafei Guo#; Jun Chen; Sangsang Hu; Ke Sun; Hongyu Hu*; Meijuan Fang*; andYuhua Xue*. Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives. Chemistry & Biodiversity, 2021, 18, e202100671. (IF= 2.74)

7. Hongyu Hu#; Jun Wu#; Jianfeng Yuan; Zhenni Wang; Chenfan Li; Xiaoyan Yan; Meijuan Fang*; Shengxian Zhao*; Synthesis and Biological Activity Research of 4-Substitued-1-(2-methyl-6-(pyri-din-3-yl)-nicotinoyl) Semicarbazides. Chinese Journal of Organic Chemistry, 2019, 39, 2507～2514. (IF= 1.65)

8. Hongyu Hu#; Jun Wu#; Mingtao Ao; Huiru Wang; Tongtong Zhou; Yuhua Xue; Yingkun

Qiu; Meijuan Fang*; Wu Zhen*. Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents. Chemical Biology& Drug Design, 2016, 88(5): 766-778. (IF = 2.87)

9. Rongdiao Liu #; Jun Wu #; Rui Shao; Yuhua Xue*. Mechanism and factors that control HIV-1 transcription and latency activation. Journal of Zhejiang University-SCIENCE B, 2014, 15(5):455-465. (IF = 5.55)

10. Zichong Li ; Jun Wu ; Chavez, Leonard ; Hoh, Rebecca ; Deeks, Steven G. ; Pillai, Satish K; Qiang Zhou* . Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency, PLoS Pathogens, 2019, 15 (1): 0-e1007498. (IF= 6.82)

11. Cong Wang; Huiru Wang; Zhenrui Pan; Jun Wu; Yafei Guo; Jing Zhang; Zixun Xiang; Wei Lu*; Yuhua Xue*. Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP. Disease markers, 2022, 6055347. (IF= 3.4)

12. Xiaoping Zhou#; Guoliang Wang#; Xiaoya An; Jun Wu; Kai Fan; Lina Xu; Cheng Li; Yuhua Xue*. Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment. Environmental Pollution, 2022, 303,119126. (IF= 8.07)

13. Chen Wang; Jiayan Sang; Jiawei Wang; Mingyan Su; Jennifer S. Downey; Qinggan Wu; Shida Wang; Yongfei Cai; Xiaozheng Xu; Jun Wu; Dilani B. Senadheera; Dennis G. Cvitkovitch; Lin Chen; Steven D. Goodman; Aidong Han. Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains. PLOS Biology, 2013,11(2): e1001493. (IF= 9.1)

科研项目：

1.中国博士后科学基金会, 中国博士后科学基金第69批面上资助一等, 2021M690095, 新型氮杂吲哚类化合物G7a高效特异性阻断新冠病毒Spike蛋白与宿主ACE2受体结合的机制研究, 2021-07 至 2022-07, 12万元, 结题, 主持

获奖：

1. 厦门大学生命科学与人类健康学科群2020年度优秀博士后资助