心肌重构及细胞内信号转导研究组

2021-05-06

心肌重构及细胞内信号转导研究组

心肌重构是多种心脏疾病发展至心衰的重要原因。压力过负荷、心肌缺血、衰老、炎症以及多种激素等均可诱导心肌重构，大量临床研究及动物实验发现，改善心肌重构可以有效减缓心力衰竭的发生发展。但目前关于心肌重构的详细分子机制尚未阐明。因此，明确心肌重构的细胞内调控机制，寻找可以延缓重构的生物学靶点具有十分重要的临床意义。

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基础研究方向

1. 冠心病与动脉粥样硬化所致心肌重构的发病机制及治疗

2. 急性心梗所致心肌重构的发生机制及治疗

3. 压力过负荷所致心肌重构的发生机制及治疗

临床研究方向

1. 运动康复对室壁瘤患者远期预后的研究

2. 急性心梗患者分次手术策略的RCT研究

研究团队

研究组组长（PI）：戴翠莲教授

Co-PI:宋娟博士。

研究组成员：李穗吉博士；陈翔博士；张鹏博士；苏柳杭医师；聂美玲医师。

研究生：陈林健；马鸿斌；齐瑞强；倪威；王琳。

部分代表文章

1. Dai C#, Yao Xl#, Gordon EM#, Barochia A, Cuento RA, Kaler M, Meyer KS, Keeran KJ, Nugent GZ, Jeffries KR, Qu X, Yu ZX, Aponte A, Gucek M, Dagur PK, McCoy JP, Levine SJ*. A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163-/- mice.Mucosal Immunol. 2016 May;9(3):702-17.

2. Cuilian Dai#, Xianglan Yao#, Boris Vaisman, Todd Brenner, Katharine S. Meyer, Karen J. Keeran, Gayle Z. Nugent, Xuan Qu, Zu-Xi Yu, Alan T. Remaley and Stewart J. Levine*. The ABCA1 Transporter Attenuates Ovalbumin-induced Neutrophilic Airway Inflammation. Am J Respir Cell Mol Biol. 2014 Nov;51(5):626-36.

3. Dai C, Yao X, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Dagur PK, McCoy JP, Remaley AT, Levine SJ*. Apolipoprotein A-I Attenuates Ovalbumin-induced Neutrophilic Airway Inflammation via a G-CSF-dependent Mechanism. Am J Respir Cell Mol Biol. 2012 Aug;47(2):186-95

4. J. Song#, Y. Zhu#, J. Li, J. Liu, Y. Gao, T. Ha, L. Que, L. Liu, G. Zhu, Q. Chen, Y. Xu, C. Li, Y. Li*. Pellino1-mediated TGF-beta1 synthesis contributes to mechanical stress induced cardiac fibroblast activation. J Mol Cell Cardiol 2015 (79) 145-156.

5. Min Fan#, Juan Song#, Yijie He, Xin Shen, Jiantao Li, Linli Que, Guoqing Zhu, Quan Zhu, Xin Cai, Tuanzhu Ha, Qi Chen, Yong Xu, Chuanfu Li, Yuehua Li*. The TIR/BB-loop Mimetic AS-1 Attenuates Mechanical Stress-induced Cardiac Fibroblast Activation and Paracrine Secretion via Modulation of Large Tumor Suppressor Kinase 1. BBA - Molecular Basis of Disease 2016 (1862,6) 1191-1202.

6.Juan Song, QifeiXie, Lin Wang, Yi Lu, Peijing Liu, Ping Yang, Rui Chen, Chen Shao, Chen Qiao, Zhongqun Wang Jinchuan Yan. The TIR/BB-loop mimetic AS-1 prevents Ang II-induced hypertensive cardiac hypertrophy via NF-κB dependent downregulation of miRNA-143. Scientific Reports. (2019) 9:6354.

7. QifeiXie, Suiji Li, Yun Gao, Ling Jin, Cuilian Dai*, Juan Song*. Ergosterol Attenuates Isoproterenol‑Induced Myocardial Cardiotoxicity. 2020, Cardiovascular Toxicology. https://doi.org/10.1007/s12012-020-09574-6.

8.SJ L#, Z G#, J K, JJ Z, F Y, TW K, T S, S Y, I S, XS Q, NL T, TS R, L T and SL C*. Cutoff Value and Long-Term Prediction of Clinical Events by FFR Measured Immediately After Implantation of a Drug-Eluting Stent in Patients With Coronary Artery Disease: 1- to 3-Year Results From the DKCRUSH VII Registry Study. JACC Cardiovascular interventions. 2017;10:986-995.

9.Xiang Chen; Xiaofei Gao; Jing Kan; Rajiv Shrestha; Leng Han; Shu Lu; Xuesong Qian; Bill D. Gogas; Junjie Zhang*; Shao-Liang Chen*; Overlapping Drug-Eluting Stent Is Associated with Increased Definite Stent Thrombosis and Revascularization: Results from 15,561 Patients in the AUTHENTIC Study, Cardiovasc Drugs Ther, 2020, https://doi.org/10.1007/s10557-020-07094-7.

10. Xiang Chen#; Xiaobo Li#; Jun-Jie Zhang#; Yaling Han; Jing Kan; Lianglong Chen;ChunguangQiu; TeguhSantoso; ChootopolPaiboon; Tak W. Kwan; Imad Sheiban;Martin B. Leon; Gregg W. Stone; Shao-Liang Chen*; Clinical Outcomes After DK Crush Versus Provisional Stenting of Left Main Distal Bifurcation Lesions: The Three Years Follow-Up Results of the DKCRUSH-V Randomized Trial, JACC Cardiovasc Interv, 2019 10 14;1219(19).

研究组地址：厦门市湖里区金山路2999号门诊楼5楼

联系人和联系电话：宋娟 17768797121