动脉粥样硬化分子机制与临床研究组
动脉粥样硬化分子机制与临床研究组
心血管疾病是全球死亡的最主要原因，给个人和社会带来沉重经济负担。动脉粥样硬化是冠心病等心脑血管疾病的病理基础，阐明分子机制及免疫炎症调控在动脉粥样硬化中的作用，可为临床动脉粥样硬化的防治提供新思路。复杂冠脉病变是冠心病中较严重的类型,手术风险高、操作难度大，我们通过开展临床研究为复杂病变患者选择合适的血运重建策略，并研究新型冠脉内影像学、功能学等评价技术在介入策略制定中的应用。
基础研究方向
1. 冠心病与动脉粥样硬化的分子机制及炎症免疫调控
2. 心血管离子通道与药理学研究
3. 心血管疾病分子影像学与功能学
临床研究方向
1. 复杂冠状病变介入治疗策略
2. 血管内影像学与功能学评估在冠脉介入治疗中的应用
研究团队
研究组组长（PI）： 肖国胜 教授/主任医师/硕士研究生导师
研究组成员：陈水龙主任医师、吕佳蓝副主任医师、王桂香副主任医师/医学博士、曹龙兴主治医师/医学博士/助理教授、康慧元主治医师、陈晓芳主治医师、柏中胜主治医师/医学博士
研究生：张晓敏、彭朝梅
部分代表文章
1. Wang Y, Xiao G, Zhang G, Wang B, Lin Z, Saiwha HD, You H, Lai K, Su M, Wen H, Wang J, Annest L, Tse G. A transcatheter procedure for direct modification of the aneurysmatic left ventricle. EuroIntervention. 2021 Apr 2;16(18):e1541-e1543. doi: 10.4244/EIJ-D-19-00225. PMID: 31985453.
2. Xiao GS, Zhang YH, Wang Y, Sun HY, Baumgarten CM, Li GR. Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes. Br J Pharmacol. 2018 Aug;175(16):3422-3432. doi: 10.1111/bph.14392. Epub 2018 Jul 8. PMID: 29900525; PMCID: PMC6057899.
3. Xiao GS, Zhang YH, Wu W, Sun HY, Wang Y, Li GR. Genistein and tyrphostin AG556 decrease human atrial ultra-rapidly activating delayed rectifier potassium current by inhibiting EGFR tyrosine kinase. Br J Pharmacol 2017 Mar;174(6):454-467.
4. Jie LJ, Wu WY, Li G, Xiao GS, Zhang S, Li GR, Wang Y. Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. Br J Pharmacol 2017 Feb;174(3):254-266.
5. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016 Nov 7;6:36435. doi: 10.1038/srep36435.
6. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016 May 10;6:25743. doi: 10.1038/srep25743.
7. Che H, Xiao GS, Sun HY, Wang Y, Li GR. Functional TRPV2 and TRPV4 channels in human cardiac c-kit+ progenitor cells. J Cell Mol Med. 2016 Feb 10. doi: 10.1111/jcmm.12800. [Epub ahead of print]
8. Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2015 Dec 12;104:61-69.
9. Chen KH, Xu XH, Sun HY, Du XL, Liu H, Yang L, Xiao GS, Wang Y, Jin MW, Li GR. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes. Heart Rhythm. 2015 Nov 17. pii: S1547-5271(15)01429-0.
10. Che H, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015 Nov 15;309(10):H1772-81.
研究组地址：厦门市湖里区金山路2999号住院部8楼
联系人和联系电话：肖国胜 0592-2292343
